Flaviviruses Are Sensitive to Inhibition of Thymidine Synthesis Pathways
نویسندگان
چکیده
منابع مشابه
Flaviviruses are sensitive to inhibition of thymidine synthesis pathways.
Dengue virus has emerged as a global health threat to over one-third of humankind. As a positive-strand RNA virus, dengue virus relies on the host cell metabolism for its translation, replication, and egress. Therefore, a better understanding of the host cell metabolic pathways required for dengue virus infection offers the opportunity to develop new approaches for therapeutic intervention. In ...
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That the regulation of cell division and deoxyribonucleic acid synthesis is subject to some kind of chemical control in higher organisms is widely accepted (2-5). Davidson (2) has suggested that deoxyribonucleic acid synthesis takes place at critical concentrations of the deoxyribonucleoside triphosphates and that these compounds are components of a homeostatic mechanism. There are now at least...
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Here, we examined the potential of blocking the thymidine de novo synthesis pathways for sensitizing melanoma cells to the nucleoside salvage pathway targeting endogenous DNA irradiation. Expression of key nucleotide synthesis and proliferation enzymes thymidylate synthase (TS) and thymidine kinase 1 (TK1) was evaluated in differentiated (MITFhigh [microphthalmia-associated transcription factor...
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. Studies from several laboratories have shown that labeled glucose is converted to B-deoxy hexoses without randomization of the label when microorganisms are grown on n-glucose-l-C14 or n-glucose-MY4 as the sole source of carbohydrate (l-3). Evidence of this type has been interpreted to indicate a conversion of the intact hexose moiety to the deoxy compound without scission of the hexose carbo...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2013
ISSN: 0022-538X
DOI: 10.1128/jvi.00101-13